The United States Department of Health and Human Services (HHS) is the U.S. government's principal agency for protecting the health of all Americans. HHS provides essential human services, especially for those who are least able to help themselves. The Office of Global Affairs (OGA) is part of the HHS Office of the Secretary. OGA promotes the health and well-being of Americans and of the world's population by advancing HHS's global strategies and partnerships and working with USG agencies in the coordination of global health policy. 

OGA serves as the primary point within HHS for setting priorities for international engagements and developing and strengthening relationships with USG agencies, foreign ministries of health, multilateral partners at headquarters and in the field, and with civil society and the private sector.  OGA provides policy recommendations and staff support to the Secretary, Deputy Secretary and other senior HHS leadership in the areas of global health and social issues and coordinates international health and social matters across HHS, including major crosscutting global health initiatives. OGA's USG partners include the National Security Staff, the Department of State, the Department of Defense and the U.S. Agency for International Development, among others.  HHS has a range of relationships with most of the world's ministries of health. Multilateral partners include the World Health Organization, the Pan American Health Organization, the Global Fund to Fight AIDS, Tuberculosis and Malaria, the UN Joint Program on HIV/AIDS (UNAIDS), the Organization for Economic Cooperation and Development, and the  GAVI Alliance.